Study M255

Study name

Li JJ 2007

Title

[Detection of frontal biochemical abnormalities in youth with major depression using three-dimensional hydrogen proton MR spectroscopy and diffusion tensor imaging]

Overall design

The aim of this study was to determine whether the major depression had neuro-biochemical abnormalities in the frontal lobe by using three-dimensional 1H proton spectroscopy (3D 1H MRS) and diffusion tensor imaging (DTI). Patients with major depression (depression group, n = 54) and normal age-marched controls (control group, n = 50) were involved. MRI and 3D 1H MRS brain scans were performed on all participants. In the bilaterally dorsolateral white matter and cingulate gray matter of the frontal lobe, the absolute levels of N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI) and creatine (Cr) were measured, and their ratios of metabolite to Cr levels were computed from the absolute values.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

CCMD-3 diagnosed MDD

Sample size

104

Tissue

Central; Brain; Dorsolateral white matter;

Central; Brain; Anterior cingulate cortex;

Platform

MRS; MRS: GE Signa 1.5 T Twinspeed/Excite II scanner (General Electric Medical Systems, USA);

PMID

N/A

DOI

10.3321/j.issn:1003-3289.2007.05.007

Citation

Li JJ, Kong XQ, Lin MF, et al. [Detection of frontal biochemical abnormalities in youth with major depression using three-dimensional hydrogen proton MR spectroscopy and diffusion tensor imaging]. Chinese Journal of Medical Imaging Technology 2007;23(5):659-62. (Article in Chinese)

Metabolite

myo-Inositol;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds;

myo-Inositol/(Creatine and Phosphocreatine) ratio;