Study M253
Study name | Gabbay V 2007 |
Title | Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study |
Overall design | This study extends the use of this modality to pediatric major depression to test the hypothesis that adolescents with major depression have elevated concentrations of striatal choline and creatine and lower concentrations of N-acetylaspartate. Adolescents (ages 12-19 years, eight female) who had major depressive disorder for at least 8 weeks and a severity score of 40 or higher on the Children's Depression Rating Scale-Revised (depression group, n = 14) and healthy comparison adolescents (control group, n = 10) group-matched for gender, age, and handedness were enrolled. All underwent three-dimensional 3-T 1H-MRS at high spatial resolution (0.75-cm3 voxels). Relative levels of choline, creatine, and N-acetylaspartate in the left and right caudate, putamen, and thalamus were scaled into concentrations using phantom replacement, and levels were compared for the two cohorts. Metabolite quantification was normalized to phantom. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD, CDRS-R >= 40 |
Sample size | 24 |
Tissue | Central; Brain; Caudate; Central; Brain; Putamen; Central; Brain; Thalamus; |
Platform | MRS; MRS: Trio 3-T full-body MRI scanner (Siemens AG, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Gabbay V, Hess DA, Liu S, et al. Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study. Am J Psychiatry 2007;164(12):1881-9. |
Metabolite |
