Study M252
Study name | Ende G 2007 |
Title | Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression |
Overall design | The purpose of the present study was to determine whether MR-detectable alterations of choline-containing compounds in two key neural systems involved in major depression disorder namely the hippocampus and the basal ganglia can be detected. Multislice proton magnetic resonance spectroscopic imaging was applied in patients with major depressive disorder (depression group, n = 11) and matched healthy subjects (control group, n = 10). Voxels were selected from the left and right side of the hippocampus and the putamen. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 21 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Putamen; |
Platform | MRS; MRS: 1.5 T Siemens Vision system (Magnetom VISION, Siemens, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Ende G, Demirakca T, Walter S, et al. Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression. Eur Arch Psychiatry Clin Neurosci 2007;257(1):36-9. |
Metabolite |
