Study M250
Study name | Sartorius A 2006 |
Title | Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2 |
Overall design | The aim of this study was to investigate if an electroconvulsive shock treatment (ECS) induced choline rise correlates with enhanced expression of phospholipase A2 (PLA2) we compared the expression level of PLA2 in hippocampi of ECS treated rats and control rats. Fifteen animals were treated with an ECS course before measurements. In short, they received 6 ECS sessions, one daily. MR spectroscopy (MRS) was performed the next day after the last ECS session. From the initial 54 hippocampi, 6 were excluded and thus 48 hippocampi were included into the analysis, 23 from control (control group) and 25 from post ECS animals (ECT group). Hippocampal choline-containing compounds (Cho) determined with 1H MRS. Metabolite quantification was reported relative to N-acetylaspartate as the reference peak. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 27 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 4.7 T MSL-X11 BIOSPEC experimental scanner (Bruker BioSpin GmbH, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Sartorius A, Schloss P, Vollmayr B, et al. Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2. World J Biol Psychiatry 2006;7(4):246-50. |
Metabolite |
