Study M248

Study name

MacMaster FP 2006

Title

Choline in pediatric depression

Overall design

The aim of this study was to examine choline levels in the prefrontal cortex of youth with major depressive disorder (MDD) using proton magnetic resonance spectroscopy (1H-MRS). Subjects aged 10 to 18 years old with MDD (depression group, n = 12) and age and sex-matched healthy controls (control group, n = 12) participated in this study. All subjects were treatment naive at the time of the scan. A long echo 1H-MRS scan was acquired from the right prefrontal cortex (4 cc) in all subjects. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

24

Tissue

Central; Brain; Prefrontal cortex;

Platform

MRS; MRS: Siemens Magnetom Vision 1.5 Tesla scanner;

PMID

19529805

DOI

N/A

Citation

MacMaster FP, Kusumakar V. Choline in pediatric depression. Mcgill J Med 2006;9(1):24-7.

Metabolite

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;