Study M246

Study name

Czeh B 2005

Title

Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression

Overall design

The aim of this study was to examine the effects of SLV-323, a novel neurokinin 1 receptor (NK1R) antagonist, in the chronic psychosocial stress paradigm of adult male tree shrews. Animals were divided into the following 3 groups (n = 6 in each group): (1) control group, (2) stress group (daily psychosocial conflict stress), (3) stress + SLV-323 group (daily psychosocial conflict stress plus SLV-323 treatment at the dose of 20 mg/kg). The psychosocial conflict stress procedure lasted for 5 weeks, and SLV-323 was administered orally during the last 4 weeks of the model building period. Brain metabolite concentrations were determined in vivo by proton magnetic resonance spectroscopy. The cerebral metabolite concentrations of N-acetyl-aspartate (NAA), total creatine (Cr), choline-containing compounds (Cho), and myo-inositol (Ins) were determined in all animals. Additional MRS data for animals of the control and the stress group were available from a cohort of age-matched males acquired in multiple studies. Norepinephrine excretion was monitored from daily urine samples, and quantified by LC-MS. Metabolite quantification was reported relative to brain water concentration.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Non-human primate; Tree shrew;

Categories of depression

Animal model; Other animal model; Other animal model;

Criteria for depression

Not reported

Sample size

38

Tissue

Central; Brain; Brain;

Peripheral; Urine; Urine;

Platform

MRS; MRS: 2.35 T MRBR 4.7/400 mm magnet (Magnex Scientific, Abingdon, England) with DBX system (Bruker BioSpin, Ettlingen, Germany);

MS-based; LC-MS: not reported;

PMID

15726334

DOI

10.1007/s00213-005-2184-8

Citation

Czeh B, Pudovkina O, van der Hart MG, et al. Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression. Psychopharmacology 2005;180(3):548-57.

Metabolite

N-Acetyl-L-aspartic acid;

Norepinephrine;

Choline-containing compounds;

Creatine and Phosphocreatine;