Study M244

Study name

Rosenberg DR 2005

Title

Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study

Overall design

With single voxel proton magnetic resonance spectroscopy, this study reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in pediatric major depressive disorder (MDD) patients (depression group, n = 14) versus case-matched healthy control subjects (control group, n = 14). These changes might reflect a change in glutamate, glutamine, or their combination. Fitting to individually quantify anterior cingulate glutamate and glutamine was performed in these subjects with a new basis set created from data acquired on a 1.5 Tesla General Electric Signa (GE Healthcare, Waukesha, Wisconsin) magnetic resonance imaging scanner with LCModel (Version 6.1-0; Max-Planck-Institute, Gottingen, Germany). Metabolite quantification was reported in absolute concentrations.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

28

Tissue

Central; Brain; Anterior cingulate cortex;

Central; Brain; Occipital cortex;

Platform

MRS; MRS: 1.5 Tesla General Electric Signa (GE Healthcare, Waukesha, Wisconsin) magnetic resonance imaging scanner;

PMID

16084860

DOI

10.1016/j.biopsych.2005.05.007

Citation

Rosenberg DR, Macmaster FP, Mirza Y, et al. Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study. Biol Psychiatry 2005;58(9):700-4.

Metabolite

L-Glutamic acid;