Study M243
Study name | Caetano SC 2005 |
Title | Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients |
Overall design | The aim of this study was to compare the neurochemistry of the left dorsolateral prefrontal cortex (DLPFC) of children and adolescents suffering from major depressive disorder (MDD) with that of age- and gender-matched healthy controls using used 1H spectroscopy. We conducted single voxel proton magnetic resonance spectroscopy (1H MRS) of the left DLPFC in depressed children and adolescents (depression group, n = 14) and male matched healthy controls (depression group, n = 22). The LC Model software package was used to quantify the 1H metabolites. Reliable metabolites (NAA, PCr + Cr, GPC + PC, Ino, Gln, and Glu) were used in the analysis. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 36 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 1.5 T Philips Intera 8.1.1. scanner; |
PMID | |
DOI | |
Citation | Caetano SC, Fonseca M, Olvera RL, et al. Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients. Neurosci Lett 2005;384(3):321-6. |
Metabolite |
