Study M241
Study name | Rosenberg DR 2004 |
Title | Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls |
Overall design | The aim of this study was to examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of pediatric patients with obsessive-compulsive disorder (OCD) without major depressive disorder (MDD) versus pediatric patients with MDD without OCD and healthy controls. Single-voxel proton magnetic resonance spectroscopic examinations of the anterior cingulate cortex were conducted in psychotropic-naive children and adolescents with MDD without OCD (depression group, n = 14), 10 to 19 years of age, and case-matched healthy controls (control group, n = 14). Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 28 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: Signa 1.5-Tesla unit (Horizon LX software, General Electric Medical Systems, Milwaukee, WI); |
PMID | |
DOI | |
Citation | Rosenberg DR, Mirza Y, Russell A, et al. Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls. J Am Acad Child Adolesc Psychiatry 2004;43(9):1146-53. |
Metabolite |
