Study M240
Study name | Bhagwagar Z 2004 |
Title | Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor |
Overall design | In this study, magnetic resonance spectroscopy (MRS) was used to assess the effect of acute administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on cortical levels of gamma-aminobutyric acid (GABA). Ten healthy volunteers received either intravenous citalopram (10 mg) or saline in a randomized, double-blind, crossover design. Subjects were scanned on two occasions after receiving either intravenous citalopram (10 mg) or saline over 30 minutes in a randomized, double-blind, crossover design. The occipital GABA/creatine ratio was measured with a proton MR spectral editing technique from subjects between 40 and 65 minutes after completion of the infusion. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 10 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 3-T Varian-Inova spectrometer; |
PMID | |
DOI | |
Citation | Bhagwagar Z, Wylezinska M, Taylor M, et al. Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor. Am J Psychiatry 2004;161(2):368-70. |
Metabolite |
