Study M239
Study name | Mirza Y 2004 |
Title | Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression |
Overall design | The aim of this study was to examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of children with major depressive disorder (MDD). Single-voxel proton magnetic resonance spectroscopic (1H-MRS) examinations of the anterior cingulate cortex were conducted in psychotropic-naive children and adolescents with MDD (depression group, n = 13) and age- and sex-matched healthy children and adolescents (control group, n = 13). Ten of the 13 MDD patient-control pairs also had a 1H-MRS examination of occipital cortex. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 26 |
Tissue | Central; Brain; Anterior cingulate cortex; Central; Brain; Occipital cortex; |
Platform | MRS; MRS: Signa Horizon 1.5 Tesla unit (GE Medical Systems, Milwaukee, WI); |
PMID | |
DOI | |
Citation | Mirza Y, Tang J, Russell A, et al. Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression. J Am Acad Child Adolesc Psychiatry 2004;43(3):341-8. |
Metabolite |
