Study M238
Study name | Vythilingam M 2003 |
Title | Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study |
Overall design | The aim of this study was to test the hypothesis that patients with major depressive disorder (MDD) have focal neuronal and membrane abnormalities localized in the subcortical region using 1H-MRS. Whole brain and subcortical measures of choline (Cho), creatine (Cr), N-acetyl-L-aspartate (NAA) and myo-inositol (mI) were obtained in patients with MDD (depression group, n = 18) and control subjects (control group, n = 20) using automated two-dimensional CSI 1H-MRS. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-III-R diagnosed MDD |
Sample size | 38 |
Tissue | Central; Brain; Brain; Central; Brain; Caudate; Central; Brain; Thalamus; Central; Brain; Putamen; |
Platform | MRS; MRS: 1.5 T General Electric Signa system; |
PMID | |
DOI | |
Citation | Vythilingam M, Charles HC, Tupler LA, et al. Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study. Biol Psychiatry 2003;54(7):744-50. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
