Study M237
Study name | Silveri MM 2003 |
Title | S-adenosyl-L-methionine: effects on brain bioenergetic status and transverse relaxation time in healthy subjects |
Overall design | The aim of this study was to investigate whether alterations in cerebral phosphorus metabolites could be observed with phosphorus magnetic resonance spectroscopy (31P MRS) in a healthy cohort after oral S-adenosyl-L-methionine (SAMe) treatment. Twelve subjects self-administered 1600 mg of oral SAMe daily for 4 weeks. Phosphorus spectra and transverse relaxation time (T2RT) were acquired at baseline and after treatment using a 1.5 Tesla scanner. The ratio of area of each peak to the total phosphorus area was then calculated and reported as mole percent metabolite value. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 12 |
Tissue | Central; Brain; Brain; |
Platform | MRS; MRS: 1.5 Tesla Signa Scanner (General Electric Medical Systems, Milwaukee, WI); |
PMID | |
DOI | |
Citation | Silveri MM, Parow AM, Villafuerte RA, et al. S-adenosyl-L-methionine: effects on brain bioenergetic status and transverse relaxation time in healthy subjects. Biol Psychiatry 2003;54(8):833-9. |
Metabolite |
