Study M236
Study name | Sartorius A 2003b |
Title | Choline rise in the rat hippocampus induced by electroconvulsive shock treatment |
Overall design | The aim of this study was to test whether electroconvulsive treatment (ECT) unspecifically induces an increase of magnetic resonance spectroscopy (MRS)-detectable choline concentration in the rat hippocampus. Rats received a 6-day course of daily electroconvulsive shock (ECS) treatment and were observed with MRS. Animals underwent a first MRS scan (pre-ECS) at day 1. During the following 6 days, animals were treated with ECS (administered once daily on days 2-7). A second MRS scan (post-ECS) was obtained at day 8. Rat hippocampi (n = 28) were investigated via magnetic resonance spectroscopy and signal intensities of choline (Cho), total creatine (tCr), and N-acetyl aspartate (NAA) were measured and expressed as ratios. Metabolite quantification was reported relative to total creatine or N-acetyl aspartate as the reference peak. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 14 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 4.7 T MSL-X11 BIOSPEC experimental scanner (Bruker Medical GmbH, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Sartorius A, Neumann-Haefelin C, Vollmayr B, et al. Choline rise in the rat hippocampus induced by electroconvulsive shock treatment. Biol Psychiatry 2003;53(7):620-3. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
