Study M235
Study name | Pfleiderer B 2003 |
Title | Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients |
Overall design | The aim of this study was to assess the effect of successful electroconvulsive therapy (ECT) on glutamate/glutamine (Glx) levels in the anterior cingulum. The left anterior cingulum of severely depressed unipolar patients (depression group, n = 17) was measured by 1H STEAM spectroscopy before and after ECT, and the results were compared with those for age- and gender-matched controls (control group, n = 17). Patients required a mean of 12.5 +- 5.2 ECT treatments. Response was defined as a Montgomery-Asberg rating scale (MADRS) reduction > 60% of baseline scores. Ten patients were non-responders (non-responder group), and 7 patients were responders (responder group). Metabolite quantification was reported in institutional units. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 34 |
Tissue | Central; Brain; Anterior cingulate; |
Platform | MRS; MRS: 1.5 T STEAM spectroscopy (Magnetom SP, Siemens, Erlangen, FRG); |
PMID | |
DOI | |
Citation | Pfleiderer B, Michael N, Erfurth A, et al. Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Res 2003;122(3):185-92. |
Metabolite |
