Study M232
Study name | Sartorius A 2003a |
Title | Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment |
Overall design | In this study, animals were trained for learned helplessness at day 1 with an inescapable electric foot shock paradigm and tested at day 2 with the same paradigm including an escape condition. Animals failing to escape in > 10 of 15 trials were defined as learned helpless (LH) and animals with < 5 of 15 failed trials as not learned helpless (NLH). Further MRS investigations were performed on LHs (LH group, n = 6) and NLHs (NLH group, n = 7). Helpless and non-helpless rats received a course of daily administered electroconvulsive shocks (ECS) for 6 days. Magnetic resonance spectroscopy (MRS) measurements were performed on a 4.7 T animal scanner with an average voxel size within the rat hippocampus of 10 ml. Metabolite quantification was reported relative to total creatine or N-acetyl aspartate as the reference peak. |
Study Type | Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; Animal model; Learned helplessness model; Learned helplessness model; |
Criteria for depression | Active avoidance test |
Sample size | 13 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 4.7 T MSL-X11 BIOSPEC experimental scanner (Bruker Medical GmbH, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Sartorius A, Vollmayr B, Neumann-Haefelin C, et al. Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment. Neuroreport 2003;14(17):2199-201. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
