Study M229
Study name | Michael N 2003a |
Title | Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression |
Overall design | The aim of this study was to detect probable neurotrophic changes during electroconvulsive therapy (ECT). For this purpose, N-acetylaspartate (NAA), an amino acid exclusively located in neurons, and other brain metabolites such as glutamine/glutamate (Glx), choline (Cho), and creatine (Cr) were measured in patients by localized proton magnetic resonance spectroscopy. A total of 28 severely depressed patients (DSM-IV) were enrolled, and the left amygdalar region was investigated by proton STEAM spectroscopy before and after unilateral ECT. The sample consisted of unipolar depressives (depression group, n = 13) and bipolar depressives (bipolar depression group, n = 15). Age- and gender-matched healthy controls (depression control group, n = 13; bipolar control group, n = 15) were enrolled. Patients required a mean of 11.6 +- 5 ECT treatments. Metabolite quantification was reported in institutional units. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 26 |
Tissue | Central; Brain; Amygdala; |
Platform | MRS; MRS: 1.5 T STEAM spectroscopy (Magnetom SP, Siemens, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Michael N, Erfurth A, Ohrmann P, et al. Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression. Neuropsychopharmacology 2003;28(4):720-5. |
Metabolite |
