Study M228
Study name | Gruber S 2003 |
Title | Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1H-MRS at 3 Tesla |
Overall design | The aim of this study was to compare metabolic differences in the frontal brain of depressed patients versus age- and sex-matched controls using proton magnetic resonance spectroscopy and absolute quantification of metabolites (NAA, Cr, Cho, mI) at 3 Tesla. Short-echo-time stimulated echo acquisition mode (TE/TM/TR = 20/30/6000 milliseconds) was applied in the prefrontal region of depressed patients (depression group, n = 17) and age- and sex-matched controls (control group, n = 17). Metabolic ratios, ie, N-acetyl-aspartate/creatine (Cr), choline/Cr, and myo-inositol/Cr, and absolute concentrations (using internal water as a reference together with LCModel-based spectra fitting) were calculated and compared between groups and published reference data. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed depression, HAMD-17 > 17 |
Sample size | 34 |
Tissue | Central; Brain; Frontal lobe; |
Platform | MRS; MRS: 3 T whole-body imager (Medspec S300-DBX, Bruker Medical, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Gruber S, Frey R, Mlynarik V, et al. Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1H-MRS at 3 Tesla. Invest Radiol 2003;38(7):403-8. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
