Study M227
Study name | Grachev ID 2003 |
Title | Association between dorsolateral prefrontal N-acetyl aspartate and depression in chronic back pain: an in vivo proton magnetic resonance spectroscopy study |
Overall design | The aim of this study was to examine the interrelationships between regional brain NAcetyl aspartate levels (NAA, as identified by in vivo proton magnetic resonance spectroscopy in the right and left dorsolateral prefrontal cortex [DLPFC], orbitofrontal cortex, cingulate and thalamus), depression (as measured by the Beck Depression Inventory), and pain (as measured by short form of the McGill Pain Questionnaire) in chronic back pain patients with depression (depression group, n = 10), and compared to the relationship between regional brain NAA levels and depression in normal subjects (control group, n = 10). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 20 |
Tissue | Central; Brain; Cingulate; Central; Brain; Thalamus; Central; Brain; Dorsolateral prefrontal cortex; Central; Brain; Orbitofrontal cortex; |
Platform | MRS; MRS: 1.5 Tesla Signa clinical imaging instrument (General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Grachev ID, Ramachandran TS, Thomas PS, et al. Association between dorsolateral prefrontal N-acetyl aspartate and depression in chronic back pain: an in vivo proton magnetic resonance spectroscopy study. J Neural Transm 2003;110(3):287-312. |
Metabolite |
