Study M225
Study name | Kumar A 2002 |
Title | Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy |
Overall design | The aim of this study was to examine the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. Elderly patients with major depression (depression group, n = 20) and comparison subjects (control group, n = 18) similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. Both mean absolute levels and mean ratios of metabolite to creatine levels were compared across groups. Both mean absolute levels and mean ratios of metabolite to total creatine levels were compared. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 15 |
Sample size | 38 |
Tissue | Central; Brain; Anterior cingulate gray matter; Central; Brain; Dorsolateral white matter; |
Platform | MRS; MRS: GE 1.5-T MRI/magnetic resonance spectroscopy scanner (General Electric Medical Systems, Waukesha, Wis.); |
PMID | |
DOI | |
Citation | Kumar A, Thomas A, Lavretsky H, et al. Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. Am J Psychiatry 2002;159(4):630-6. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
