Study M224
Study name | Farchione TR 2002 |
Title | Proton magnetic resonance spectroscopic imaging in pediatric major depression |
Overall design | In this study, choline compounds, Nacetylaspartate, and creatine/phosphocreatine were measured in left and right dorsolateral prefrontal cortex (DLPFC) using a multislice proton magnetic resonance spectroscopic imaging sequence with validated phantom replacement methodology in treatment-naive MDD patients (depression group, n = 11), 10-16 years of age, and case-matched healthy control subjects (control group, n = 11). Both mean absolute levels and mean ratios of metabolite to total creatine levels were compared. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 22 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 1.5 T unit (General Electric, Horizon, 5.7 software, Milwaukee, WI); |
PMID | |
DOI | |
Citation | Farchione TR, Moore GJ, Rosenberg DR. Proton magnetic resonance spectroscopic imaging in pediatric major depression. Biol Psychiatry 2002;52(2):86-92. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
