Study M222
Study name | Kusumakar V 2001 |
Title | Left medial temporal cytosolic choline in early onset depression |
Overall design | The aim of this study was to clarify the possible involvement of cytosolic choline in the amygdala (anterior medial temporal region) of juvenile subjects with major depressive disorder (MDD). Age- and sex-matched MDD (depression group, n = 11) and control pairs (control group, n = 11) aged 14 to 18 years participated in long-echo proton magnetic resonance spectroscopic imaging (1H-MRSI) of the amygdala. Compounds available include N-acetyl-aspartate, creatine-phosphocreatine and choline-containing compounds. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 22 |
Tissue | Central; Brain; Amygdala; |
Platform | MRS; MRS: Siemens Magnetom Vision 1.5 Tesla scanner; |
PMID | |
DOI | |
Citation | Kusumakar V, MacMaster FP, Gates L, et al. Left medial temporal cytosolic choline in early onset depression. Can J Psychiatry 2001;46(10):959-64. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
