Study M221
Study name | Czeh B 2001 |
Title | Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine |
Overall design | The present study investigated the effect of tianeptine, a modified tricyclic antidepressant, in the chronic psychosocial stress model of adult male tree shrews (Tupaia belangeri), a model with high validity for research on the pathophysiology of major depression. Animals were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) stress group (daily psychosocial conflict stress), (3) tianeptine group (tianeptine treatment at the dose of 50 mg/kg), and (4) stress + tianeptine group (daily psychosocial conflict stress plus tianeptine treatment at the dose of 50 mg/kg). The psychosocial conflict stress procedure lasted for 5 weeks, and tianeptine was administered via tap water during the last 4 weeks of the model building period. At the end of the experiment, all animals underwent proton MRS measurements to evaluate in vivo brain metabolite concentrations of N-acetyl-aspartate, creatine and phosphocreatine, choline-containing compounds, and myo-inositol. Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Non-human primate; Tree shrew; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; Animal model; Other animal model; Other animal model; |
Criteria for depression | Not reported |
Sample size | 24 |
Tissue | Central; Brain; Brain; |
Platform | MRS; MRS: 2.35 T MRBR 4.7/400 mm magnet (Magnex Scientific, Abingdon, England); |
PMID | |
DOI | |
Citation | Czeh B, Michaelis T, Watanabe T, et al. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 2001;98(22):12796-801. |
Metabolite |
