Study M220
Study name | Steingard RJ 2000 |
Title | Increased orbitofrontal cortex levels of choline in depressed adolescents as detected by in vivo proton magnetic resonance spectroscopy |
Overall design | The aim of this study was to identify possible alterations in orbitofrontal cortex levels of cytosolic choline in adolescents with and without depression. Twenty-two depressed and 43 control adolescents were recruited. Of those recruited, usable proton magnetic resonance spectra were acquired from a voxel in the left anterior medial frontal lobe of depressed (depression group, n = 17) and healthy adolescents (control group, n = 28). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed depression |
Sample size | 45 |
Tissue | Central; Brain; Orbitofrontal cortex; |
Platform | MRS; MRS: not reported; |
PMID | |
DOI | |
Citation | Steingard RJ, Yurgelun-Todd DA, Hennen J, et al. Increased orbitofrontal cortex levels of choline in depressed adolescents as detected by in vivo proton magnetic resonance spectroscopy. Biol Psychiatry 2000;48(11):1053-61. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
