Study M219

Study name

Ende G 2000

Title

The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study

Overall design

The aim of this study was to monitor the effect of electroconvulsive therapy (ECT) on the nuclear magnetic resonance-detectable metabolites N-acetylaspartate, creatine and phosphocreatine, and choline-containing compounds in the hippocampus by means of hydrogen 1 magnetic resonance spectroscopic imaging. Patients (depression group, n = 17) received complete courses of ECT, during which repeated proton magnetic resonance spectroscopic imaging studies of the hippocampal region were performed. Individual changes during the course of ECT were compared with values obtained in control groups (control group, n = 30), including 24 healthy control subjects and patients remitted from major depression without ECT. At least 2 data sets were acquired from each patient: one before ECT started and a second after 5 or more ECT treatments within 30 hours to 10 days after ECT. A semiquantitative measure was used to report absolute integral values.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV and ICD-10 diagnosed MDD, HAMD-21 >= 19

Sample size

47

Tissue

Central; Brain; Hippocampus;

Platform

MRS; MRS: 1.5 T Siemens Vision MRI/MRS system (Erlangen, Germany);

PMID

11015811

DOI

10.1001/archpsyc.57.10.937

Citation

Ende G, Braus DF, Walter S, et al. The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study. Arch Gen Psychiatry 2000;57(10):937-43.

Metabolite

Choline-containing compounds;