Study M218
Study name | Auer DP 2000 |
Title | Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study |
Overall design | The aim of this study was to evaluate possible neurochemical alterations in the frontomesial cortex in patients with major depressive episode using in vivo proton magnetic resonance spectroscopy (1H-MRS). Single voxel 1H-MRS was performed in patients with major depressive episodes (depression group, n = 19) and age-matched healthy controls (control group, n = 18) within the anterior cingulate cortex and the parietal white matter. Absolute concentrations were estimated for N-acetyl-aspartate, choline-containing compounds, total creatine, myo-inositol, unresolved glutamate and glutamine (Glx) and glutamate alone (Glu). Voxel composition was analyzed by image segmentation into cerebrospinal fluid (CSF), grey and white matter. Metabolite quantification was reported in institutional units. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed depression |
Sample size | 37 |
Tissue | Central; Brain; Anterior cingulate cortex; Central; Brain; Parietal white matter; |
Platform | MRS; MRS: 1.5 T GE whole body scanner (Signa Advantage, GE Medical Systems, Milwaukee); |
PMID | |
DOI | |
Citation | Auer DP, Putz B, Kraft E, et al. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 2000;47(4):305-13. |
Metabolite |
