Study M215
Study name | Hamakawa H 1998 |
Title | Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders |
Overall design | Proton magnetic resonance spectra were recorded from a subcortical region containing the basal ganglia in 40 patients with affective disorders, including with bipolar disorder and with major depression and in normal controls. The following three peaks, including N-acetyl-l-aspartate (NAA), creatine plus Phosphocreatine (Cr), and choline-containing compounds (Cho), were compared between the patients of major depression in the depressive state (depression group, n = 19) and normal controls (control group, n = 20). Metabolite levels were evaluated as the peak ratios of Cho/Cr and Cho/NAA, as well as the absolute metabolite concentrations. Absolute concentration determination was also performed. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-III-R diagnosed MDD |
Sample size | 39 |
Tissue | Central; Brain; Basal ganglia; |
Platform | MRS; MRS: 1.5-T whole-body MR system (SIGNA, GE Medical Systems, Milwaukee, Wis.); |
PMID | |
DOI | |
Citation | Hamakawa H, Kato T, Murashita J, et al. Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders. Eur Arch Psychiatry Clin Neurosci 1998;248(1):53-8. |
Metabolite |
