Study M212
Study name | Moore CM 1997 |
Title | Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study |
Overall design | The aim of this study was to evaluate whether the concentration of beta-nucleoside triphosphate is lower in the basal ganglia of depressed subjects. In vivo 31P magnetic resonance spectra were acquired from a 45-cm3 region surrounding the basal ganglia of unmedicated depressed subjects (depression group, n = 35) and comparison subjects (control group, n = 18). The peak areas of the following metabolites-phosphomonoesters, inorganic phosphate, phosphodiesters, phosphocreatine, and gamma, alpha, and beta-nucleoside triphosphate were identified. For each metabolite, the peak area was normalized by the total phosphorous signal. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-III-R diagnosed MDD, HAMD-17 >= 16 |
Sample size | 53 |
Tissue | Central; Brain; Basal ganglia; |
Platform | MRS; MRS: 1.5-T scanner; |
PMID | |
DOI | |
Citation | Moore CM, Christensen JD, Lafer B, et al. Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study. Am J Psychiatry 1997;154(1):116-8. |
Metabolite |
