Study M211
Study name | Charles HC 1994 |
Title | Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy |
Overall design | The aim of this study was to test the hypotheses that choline concentrations will be elevated in depressed patients compared to age-matched controls and choline concentrations will normalize after recovery. Subjects with depression (depression group, n = 7) and matched controls (control group, n = 10) were studied using proton spectroscopy. After the initial MR exam, patients were maintained on up to 500 mg/day of nefazodone. The follow-up MRS/MRI studies were accomplished 2 to 3 months after therapy commenced. Image referenced STEAM MRS was used to select the anatomic level at the third ventricle which included cortical and noncortical gray matter (e.g., basal ganglia and thalamus) as well as white matter. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-III-R diagnosed MDD |
Sample size | 17 |
Tissue | Central; Brain; Brain; |
Platform | MRS; MRS: 1.5 Tesla GE Signa spectrometer; |
PMID | |
DOI | |
Citation | Charles HC, Lazeyras F, Krishnan KR, et al. Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry 1994;18(7):1121-7. |
Metabolite | Choline-containing compounds/(Creatinine and Phosphocreatinine) ratio; |
