Study M203
Study name | Gonzalez-Sepulveda M 2016 |
Title | Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice |
Overall design | To explore the pathological mechanisms that mediate the association between pain and depressive-like behaviours, the time-dependent effect of neuropathic pain on the development of anxiety-like and despair behaviours was studied in CD1 mice. The glutamate and serotonergic neurotransmissions were also investigated at the prefrontal cortex (PFC). Mice were divided into the following 2 groups: (1) control group (sham-operated surgery), and (2) sciatic-operated group (partial sciatic nerve ligation surgery at mid-thigh level). Despair behaviour was analysed using the tail suspension test at postsurgery day (PSD) 20, 41 and 62. Changes in neurotransmitter levels at PSD 20 in the PFC was evaluated using LC-MS/MS. The number of animals per group was as follows: 8 sham-operated mice and 7 sciatic-operated mice. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; CD-1 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test |
Sample size | 15 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; LC-MS: Acquity UPLC system with triple quadrupole (Xevo) mass spectrometer (Waters Associates, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Gonzalez-Sepulveda M, Pozo OJ, Marcos J, et al. Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice. J Psychopharmacol 2016;30(2):188-203. |
Metabolite |
