Study M201
Study name | Zhong P 2014 |
Title | Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling |
Overall design | The aim of this study was to examine how 2-arachidonoylglycerol (2-AG) signaling in the hippocampus was altered in depressive-like states and how this alteration contributed to depressive-like behavior using chronic unpredictable mild stress (CUS) as a mouse model of depression. Rats were divided into the following 2 groups: (1) control group, (2) CUS group. The CUS stress procedure lasted for 5 weeks. Six samples per group were used for LC-MS analysis. The content of 2-AG in the hippocampus was determined using isotopedilution liquid chromatography-electrospray ionization tandem mass spectrometry (LC-MS/MS). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 12 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Zhong P, Wang W, Pan B, et al. Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology 2014;39(7):1763-76. |
Metabolite |
