Study M200
Study name | Quak J 2014 |
Title | Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? |
Overall design | The aim of this study was to investigate the role of tryptophan degradation in the relationship between inflammatory markers and depressive symptoms in the Netherlands Study of Depression and Anxiety (NESDA) and hypothesized that tryptophan degradation would mediate (part of) this association. A total of 2812 participants of NESDA were included in this study, including persons with current major depressive disorder (current MDD group, n = 1042) and without major depressive disorder (no current MDD group, n = 1770). Tryptophan (TRP) and kynurenine (KYN) concentrations were determined by an automated online solid phase extraction-liquid chromatographic-tandem mass spectrometric (XLC-MS/MS) method. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 2812 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: automated online solidphase extraction-liquid chromatographic-tandem mass spectrometric (XLC-MS/MS); |
PMID | |
DOI | |
Citation | Quak J, Doornbos B, Roest AM, et al. Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? Psychoneuroendocrinology 2014;45:202-10. |
Metabolite |
