Study M199
Study name | Brand L 2011 |
Title | Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression |
Overall design | The aim of this study was to determine whether the Flinders Sensitive Line (FSL) rat, a genetic model of depression, presents with corticolimbic changes in basal acetylcholine (ACh) levels and NO/cGMP (nitric oxide/cyclic guanosine monophosphate) signalling. Ach levels were analysed in hippocampus and frontal cortex in FSL and control Flinders resistant line (FRL) rats by liquid chromatography tandem mass spectrometry. Groups of 10 FSL and 10 FRL rats each were used in the Ach analyses. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Not reported |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Frontal cortex; |
Platform | MS-based; LC-MS: Agilent 6410 liquid chromatography/mass spectrometer; |
PMID | |
DOI | |
Citation | Brand L, van Zyl J, Minnaar EL, et al. Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression. Acta Neuropsychiatr 2012;24(4):215-25. |
Metabolite |
