Study M195
Study name | Zhang J 2013 |
Title | Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress |
Overall design | The present study investigated the effect of early life stress in adolescent rats on prefrontal cortex (PFC) metabolites, serum corticosterone, and depressive-like behavior. A group of rats was subject to early life stress from postnatal day (PND) 1 to 14. A matched control group was studied. In this study, adolescent rats exposed to early life stress demonstrated depressive-like behavior and increased serum corticosterone during adolescence. Rats were divided into the following 4 groups (n = 8 in each group): (1) male control group, (2) male early life stress group (maternal separation procedure for 180 min from PND 1 to 14), (3) female control group, and (4) female early life stress group. All behavioral tests took place during adolescence between PND 30 and 38. High-resolution proton magnetic resonance spectroscopy were conducted at PND 40. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 32 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | NMR; NMR: BrukerAvance 400 MHz high-resolution (9.4 T) magnetic resonance spectrometer (Bruker Co., Germany); |
PMID | |
DOI | |
Citation | Zhang J, Abdallah CG, Chen Y, et al. Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress. Neurosci Lett 2013;545:132-7. |
Metabolite |
