Study M189
Study name | Young KD 2016 |
Title | Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression |
Overall design | The aim of this study was to test whether the ratios, kynurenic acid/3-hydroxykynurenine (KynA/3HK) and kynurenic acid/quinolinic acid (KynA/QA) were associated with autobiographical memory (AM) recall performance as well as hippocampal activity during AM recall. Thirty-five unmedicated depressed participants (depressed group) and 25 healthy controls (control group) underwent fMRI scanning while recalling emotionally-valenced AMs and provided serum samples for the quantification of kynurenine metabolites, CRP, and cytokines (IL-1RA; IL-6, TNF, interferon gamma -IFN-c, IL-10). The serum metabolite concentrations were determined by highperformance liquid chromatography (HPLC) with tandem mass spectrometry (MS/MS). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 60 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Young KD, Drevets WC, Dantzer R, et al. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain Behav Immun 2016;56:335-42. |
Metabolite |
