Study M188
Study name | Li CX 2008 |
Title | Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy |
Overall design | The aim of this study was to investigate the changes of cerebral metabolism in a depression-like rat model of chronic forced swimming stress (CFSS). The aims are to further understand the pathophysiological mechanisms underlying CFSS treatment, and to further establish the face and predictive validity of the CFSS model. CFSS-induced metabolic changes in prefrontal cortex (PFC) and hippocampus were detected using NMR. Rats were divided into the following 2 groups (n = 12 in each group): (1) control group, and (2) CFSS group. The rats in the CFSS group underwent a session of 15-min forced swimming once daily for 14 consecutive days. Six samples per group were used for MRS measurements. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | NMR; NMR: Varian INOVA-500 spectrometer; |
PMID | |
DOI | |
Citation | Li CX, Wang Y, Gao H, et al. Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy. Neurochem Res 2008;33(11):2342-9. |
Metabolite |
