Study M187

Study name

Levine J 2000

Title

Increased cerebrospinal fluid glutamine levels in depressed patients

Overall design

The aim of this study was to study the association between cerebrospinal fluid (CSF) metabolites, including glutamine, in unipolar and bipolar depressed patients versus control subjects using a proton magnetic resonance spectroscopy technique. Cerebrospinal fluid samples were obtained from 18 hospitalized patients with acute unmedicated severe depression without medical problems and compared with those of 22 control subjects.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-III-R diagnosed unipolar major depression

Sample size

40

Tissue

Central; Cerebrospinal fluid; Cerebrospinal fluid;

Platform

NMR; NMR: Bruker AM500 spectrometer (Bruker Instruments, Billerica, MA);

PMID

10745050

DOI

10.1016/S0006-3223(99)00284-X

Citation

Levine J, Panchalingam K, Rapoport A, et al. Increased cerebrospinal fluid glutamine levels in depressed patients. Biol Psychiatry 2000;47(7):586-93.

Metabolite

L-Glutamine;