Study M186

Study name

Hill MN 2009

Title

Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress

Overall design

The current study examined serum content of the endocannabinoid ligands N-arachidonylethanolamide (anandamide; AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabinoid N-acyl ethanolamine (NAE) molecules palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) under basal conditions, immediately following the Trier Social Stress Test (TSST), and 30 min thereafter, in medication-free women diagnosed with major depression (depressed group, n = 15), and healthy matched controls (control group, n = 15). Contents of AEA, 2-AG, PEA and OEA were quantified by using atmospheric pressure, chemical ionization liquid chromatography/mass spectrometry (LC-APCI-MS).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

30

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; LC-MS: not reported;

PMID

19394765

DOI

10.1016/j.psyneuen.2009.03.013

Citation

Hill MN, Miller GE, Carrier EJ, et al. Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. Psychoneuroendocrinology 2009;34(8):1257-62.

Metabolite

MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0);

Anandamide;