Study M180
Study name | Ogawa S 2018 |
Title | Plasma amino acid profile in major depressive disorder: analyses in two independent case-control sample sets |
Overall design | The aim of this study was to determine plasma levels of amino acids and related molecules in two independent case-control sample sets taking demographic, clinical variables, and multiple comparisons into account. Whether plasma amino acids levels were related to clinical variables, such as psychotropic drug doses and major depressive disorder (MDD) symptoms, was also examined. In total, 511 subjects were recruited. Sample set A consisted of 164 patients with MDD and 217 healthy controls. Sample set B consisted of 65 patients (51 dMDD; 14 in remission) and 65 controls. Plasma amino acid levels were measured using high-performance liquid chromatography for set A and liquid chromatography/mass spectrometry for set B. Plasma amino acid levels of set B (dMDD group and control group) were compared. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 116 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: LC-MS (SRL Co. Inc. Tokyo, Japan); |
PMID | |
DOI | |
Citation | Ogawa S, Koga N, Hattori K, et al. Plasma amino acid profile in major depressive disorder: analyses in two independent case-control sample sets. J Psychiatr Res 2017;96:23-32. |
Metabolite |
