Study M172
Study name | Veen C 2016 |
Title | Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression |
Overall design | The aim of this study was to investigate alterations in tryptophan breakdown in the physiological postpartum period compared to patients with severe postpartum mood disorders. In this study, 29 patients with affective psychosis, 23 patients with severe depression, 52 matched healthy postpartum women and 29 healthy non-postpartum women were recruited. Analyzes of serum tryptophan metabolites were performed using LC-MS/MS system for tryptophan, kynurenine, 3-hydroxykynurenine, kynurenic acid and 5-hydroxyindoleacetic acid. Serum tryptophan metabolites were compared between the severe postpartum depression (postpartum depression group; n = 23), the healthy postpartum control group for the postpartum depression (postpartum group; n= 29), and the healthy nonpostpartum group (control group; n= 29). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Postpartum depression; Postpartum depression; |
Criteria for depression | DSM-IV-TR diagnosed depression |
Sample size | 81 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters Acquity UPLC separations module with Xevo TQ MS triple-quadrupole mass spectrometer (Waters Corp., Milford, MA, U.S.); |
PMID | |
DOI | |
Citation | Veen C, Myint AM, Burgerhout KM, et al. Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression. J Affect Disord 2016;189:298-305. |
Metabolite |
