Study M167
Study name | Moaddel R 2015 |
Title | D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression |
Overall design | The aim of the study was to examine the relationship between baseline plasma concentrations of D-serine and its precursor L-serine and antidepressant response to (R,S)-ketamine in treatment-resistant depression (TRD) patients. Plasma samples were obtained from 21 TRD patients at baseline, 60 min before initiation of the (R,S)-ketamine infusion (40-min infusion of 50 ml of a 0.5 mg/kg dose of ketamine). Patients were classified as KET-Rs (responder group; n=8) or KET-NRs (non-responder group; n=13) based upon the difference in Montgomery-Asberg Depression Rating Scale (MADRS) scores at baseline and 230 min after infusion, with response defined as a >= 50 % decrease in MADRS score. The plasma concentrations of D-serine and L-serine were determined using liquid chromatography-mass spectrometry. |
Study Type | Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD, MADRS >= 22 |
Sample size | 21 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Shimadzu Prominence HPLC system (Shimadzu, Columbia, MD, USA) with 5500 QTRAP triple quadruple mass spectrometer (AB Sciex, Concord, ON, Canada); |
PMID | |
DOI | |
Citation | Moaddel R, Luckenbaugh DA, Xie Y, et al. D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression. Psychopharmacology 2015;232(2):399-409. |
Metabolite |
