Study M161
Study name | Li H 2014 |
Title | Rapid determination of corticosterone in mouse plasma by ultra fast liquid chromatography-tandem mass spectrometry |
Overall design | In this study, a simple, highly sensitive and specific method based on ultra-fast liquid chromatography-tandem mass spectrometry method has been developed for the quantitation of corticosterone in mouse plasma for the first time, which provides technical support for the high-throughput measurement for clinical determination of corticosterone in biological samples. Mice were divided into the following 2 groups (n = 6 in each group): (1) control group, (2) CMS group. The CMS stress procedure lasted for 3 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; Mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: UFLC system from Shimadzu Corporation (Shimadzu, Kyoto, Japan) with model Triple Quad 5500 triple quadrupole mass spectrometer (AB SCIEX, Foster City, CA); |
PMID | |
DOI | |
Citation | Li H, Liu X, Poh Y, et al. Rapid determination of corticosterone in mouse plasma by ultra fast liquid chromatography-tandem mass spectrometry. Biomed Chromatogr 2014;28(12):1860-3. |
Metabolite |
