Study M157

Study name

Paul-Savoie E 2011

Title

A deficit in peripheral serotonin levels in major depressive disorder but not in chronic widespread pain

Overall design

The current cross-sectional study sought to measure plasma serotonin levels in fibromyalgia patients, major depressive disorder (MDD) patients, and healthy controls. Twenty-nine fibromyalgia patients (fibromyalgia group), 17 MDD patients (depressed group), and 57 HC (control group) were recruited who did not differ in terms of age, sex, and the presence or absence of a regular menstrual cycle. Plasma samples were analyzed with LC-MS platform.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

74

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: Alliance 2795XE LC (Waters) with Quattro micro MS;

PMID

21415718

DOI

10.1097/AJP.0b013e31820dfede

Citation

Paul-Savoie E, Potvin S, Daigle K, et al. A deficit in peripheral serotonin levels in major depressive disorder but not in chronic widespread pain. Clin J Pain 2011; 27(6):529-34.

Metabolite

Serotonin;