Study M156
Study name | Jedel E 2011 |
Title | Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome |
Overall design | The aim of this study was to elucidate if self-reported hirsutism, body mass index (BMI) and waistline, circulating sex steroids, sex hormone-binding globulin (SHBG), insulin sensitivity and sympathetic nerve activity are associated with depression and anxiety-related symptoms in women with polycystic ovary syndrome (PCOS). Seventy-two women with PCOS, aged 21-37 years, were recruited from the community. Serum estrogens, sex steroid precursors, androgens and glucuronidated androgen metabolites were analyzed using gas and liquid chromatography/mass spectroscopy (GC-MS/LC-MS/MS). Participants were divided into two groups according to the Montgomery-Asberg Depression Rating Scale self-reported version (MADRS-S) scores, namely (1) non-depressed group (MADRS-S < 11; n = 37) and (2) depressed group (MADRS-S >= 11; n = 35). For biochemical analyses, GC-MS was used to analyze estrone (E1), estradiol (E2), dehydroepiandrosterone (DHEA), androstenedione (4-DIONE), 5-androstene-3beta 17betadiol (5-DIOL), T and 5alpha-dihydrotestosterone (DHT). LC-MS was used to analyze E1-sulfate (E1-S), DHEAS, androsterone glucuronide (ADTG), androstane-3alpha 17beta-diol-3glucuronide (3G) and androstane-3alpha 17beta-diol-17glucuronide (17G). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Montgomery-Asberg Depression Rating Scale self-reported version (MADRS-S) >= 11 |
Sample size | 72 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; GC-MS: not reported; MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Jedel E, Gustafson D, Waern M, et al. Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome. Psychoneuroendocrinology 2011; 36(10):1470-9. |
Metabolite |
