Study M155

Study name

Chen GG 2010

Title

Evidence of altered polyamine concentrations in cerebral cortex of suicide completers

Overall design

In this study, a method using high-resolution capillary gas chromatography (GC) in combination with mass spectrometry (MS) was developed for quantitation of polyamines from post-mortem brain tissue, which allowed us to accurately measure spermidine and putrescine concentrations in post-mortem brain tissues. Using this method, putrescine and spermidine levels were analyzed in a total of 126 samples from Brodmann areas 4, 8/9, and 11 (frontal cortex), from 42 subjects, comprising 16 suicide completers with major depression (depressed suicide group), 13 non-depressed suicide completers (non-depressed suicide group), and 13 control subjects (control group).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression with suicide; Depression with suicide;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

42

Tissue

Central; Brain; Frontal cortex;

Platform

MS-based; GC-MS: Agilent bench-top HP6890/MSD5973N Chemstation system (Agilent Technologies, Santa Clara, CA);

PMID

20200507

DOI

10.1038/npp.2010.17

Citation

Chen GG, Fiori LM, Moquin L, et al. Evidence of altered polyamine concentrations in cerebral cortex of suicide completers. Neuropsychopharmacology 2010; 35(7):1477-84.

Metabolite

Putrescine;

Spermidine;