Study name | Chen GG 2010 |
Title | Evidence of altered polyamine concentrations in cerebral cortex of suicide completers |
Overall design | In this study, a method using high-resolution capillary gas chromatography (GC) in combination with mass spectrometry (MS) was developed for quantitation of polyamines from post-mortem brain tissue, which allowed us to accurately measure spermidine and putrescine concentrations in post-mortem brain tissues. Using this method, putrescine and spermidine levels were analyzed in a total of 126 samples from Brodmann areas 4, 8/9, and 11 (frontal cortex), from 42 subjects, comprising 16 suicide completers with major depression (depressed suicide group), 13 non-depressed suicide completers (non-depressed suicide group), and 13 control subjects (control group). |
Type1; | |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with suicide; Depression with suicide; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 42 |
Tissue | Central; Brain; Frontal cortex; |
Platform | MS-based; GC-MS: Agilent bench-top HP6890/MSD5973N Chemstation system (Agilent Technologies, Santa Clara, CA); |
PMID | |
DOI | |
Citation | Chen GG, Fiori LM, Moquin L, et al. Evidence of altered polyamine concentrations in cerebral cortex of suicide completers. Neuropsychopharmacology 2010; 35(7):1477-84. |
Metabolite |