Study M154
Study name | Chu C 2017 |
Title | Decreased Prostaglandin D2 Levels in major depressive disorder are associated with depression like behaviors |
Overall design | In this study, ultra-performance liquid chromatography-tandem mass spectrometry was used to determine Prostaglandin D2 (PGD2) levels in the plasma of major depressive disorder patients (MDD) and in the brains of depressive mice. In Experiment 1, drug-free major depressive disorder patients (MDD group, n = 32) and healthy controls (HC group, n = 30) were recruited. In Experiment 2, an animal model of depression was constructed by exposing mice to 5 weeks of chronic unpredictable mild stress (CUMS). The mice were divided into the following 2 groups: (1) control group (n = 10 for LC-MS), (2) CUMS group (n = 7 for LC-MS). In Experiment 3, mice were divided into the following groups: (1) saline group (n = 6 for LC-MS), (2) low dose of SeCl4 group (Selenium tetrachloride treatment i.p. at a single dose of 1 mg/kg; n = 6 for LC-MS), (3) high dose of SeCl4 group (Selenium tetrachloride treatment i.p. at a single dose of 2.5 mg/kg; n = 6 for LC-MS), and (4) imipramine group (imipramine treatment i.p. at a single dose of 20 mg/kg). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; Human; |
Categories of depression | Depressive disorder; Depression; Depression; Animal model; Chronic mild stress model; Chronic mild stress model; Animal model; Other animal model; Other animal model; |
Criteria for depression | DSM-IV diagnosed MDD, sucrose preference test, forced swimming test |
Sample size | 97 |
Tissue | Peripheral; Blood; Plasma; Central; Brain; Brain; |
Platform | MS-based; LC-MS: Shimadzu Prominence LC-20AD UFLC system with AB SCIEX QTRAP 5500 triple quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Chu C, Wei H, Zhu W, et al. Decreased Prostaglandin D2 Levels in major depressive disorder are associated with depression like behaviors. Int J Neuropsychopharmacol 2017; 20(9):731-9. |
Metabolite |
