Study M153
Study name | Jeon SA 2017 |
Title | NLRP3 inflammasome contributes to lipopolysaccharide-induced depressive-like behaviors via indoleamine 2,3-dioxygenase induction |
Overall design | The aim of this study was to examine whether NLRP3 deficiency influenced depressive-like behaviors and cerebral inflammation following systemic administration of lipopolysaccharide in mice. To further assess the contribution of the NLRP3 inflammasome to the progression of depression, the effects of NLRP3 signaling on levels of indoleamine 2,3-dioxygenase were evaluated. The level of kynurenine and tryptophan was quantified in mouse brain by HPLC-MS/MS analysis. C57BL/6 and Nlrp3-/- (C57BL/6 background) mice were divided into the following 4 groups (n = 8 in each group): (1) control group, (2) LPS group, (3) Nlrp3-/- control group, and (4) Nlrp3-/- LPS group. LPS were i.p. administrated at a single dose of 1.8 mg/kg. Four samples per group were used for metabonomic analysis. Only data from wildtype mouse were used. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Tail suspension test, sucrose preference test, forced swimming test |
Sample size | 8 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: HPLC-Tandem mass spectrometry (MS/MS); |
PMID | |
DOI | |
Citation | Jeon S, Lee E, Hwang I, et al. NLRP3 inflammasome contributes to lipopolysaccharide-induced depressive-like behaviors via indoleamine 2,3-dioxygenase induction. Int J Neuropsychopharmacol 2017. Accepted. |
Metabolite |
