Study M143
Study name | Meier TB 2016 |
Title | Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder |
Overall design | The aim of this study was to test whether the serum concentrations of kynurenine pathway metabolites mediated reductions in cortical thickness in mPFC regions in major depressive disorder (MDD) using partial posterior predictive distribution mediation analysis. Unmedicated subjects who met DSM-IV-TR criteria for MDD (MDD group, n = 73) and healthy controls (control group, n = 91) completed MRI scanning using a pulse sequence optimized for tissue contrast resolution. Serum concentrations of kynurenine pathway metabolites were determined by high performance liquid chromatography (HPLC) with tandem mass spectrometry (MS/MS) detection. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 164 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: high performance liquid chromatography (HPLC) with tandem mass spectrometry (MS/MS); |
PMID | |
DOI | |
Citation | Meier TB, Drevets WC, Wurfel BE, et al. Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain Behav Immun 2016; 53:39-48. |
Metabolite |
