Study M140
Study name | Liu JY 2016 |
Title | [Effect of typical antidepressant drugs on the serum endogenous metabolites profile in rat] |
Overall design | The aim of this study was to explore the mechanism of venlafaxine, paroxetine and St. John's wort extract by comparing the changes of endogenous metabolites profile in rat serum. These three drugs were employed to intervene in rats exposed to the chronic unpredictable mild stress (CUMS). Serum samples from all of rats were collected for a 1H-NMR metabolomics analysis to find the differences of metabolic profile. All the rats were divided into 5 groups (n = 8 in each group): (1) control group, (2) CUMS group, (3) CUMS + venlafaxine group (stress plus venlafaxine treatment at the dose of 3.5 mg/kg), (4) CUMS + paroxetine group (stress plus paroxetine treatment at the dose of 1.8 mg/kg), and (5) CUMS + SJ group (stress plus St. John's wort treatment at the dose of 180 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered by gastric intubation once per day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 40 |
Tissue | Peripheral; Blood; Serum; |
Platform | NMR; NMR: Bruker AVANCE III 600 spectrometer; |
PMID | |
DOI | |
Citation | Liu J, Liu C, Jia J. [Effect of typical antidepressant drugs on the serum endogenous metabolites profile in rat]. Chin Pharm J 2016; 51(23):2018-24. (Article in Chinese) |
Metabolite | L-Leucine; |
