Study M139
Study name | Savitz J 2015a |
Title | Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder |
Overall design | The aim of this study was to compare the serum concentrations of kynurenine metabolites, measured using high performance liquid chromatography with tandem mass spectrometry, across unmedicated subjects meeting DSM-IV-TR criteria for MDD (dMDD group, n = 49), unmedicated subjects meeting DSM-IV-TR criteria for rMDD (rMDD group, n = 21), and healthy controls (control group, n = 58). Concentrations of tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine, and quinolinic acid were measured. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 128 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: high performance liquid chromatography (HPLC) with tandem mass spectrometry (MS/MS) detection; |
PMID | |
DOI | |
Citation | Savitz J, Drevets WC, Wurfel BE, et al. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun 2015; 46:55-9. |
Metabolite |
